New generation camera for thyroid gland and small organs imaging by nuclear medicine methods

The project is part of the 1. Public contest for industrial and experimental development program TREND organized by TAČR. It took the 11. place amongst all 396 projects submitted in this contest. The project will be scheduled for 4 years and it was started in 2020.

The consortium was established upon the previous long-term cooperation of all the incorporated companies.

Advacam s.r.o. is the leader of the project, it experienced several successfully finished projects in the past not only in Czech Republic, but in international scale as well. ADVACAM is responsible for the part dedicated to the development of the detectors and advanced imaging methods.

Members of the consortium are:

The main goal of the project is development of the new generation mobile robotic imaging camera prototype for thyroid gland and small organs imaging by nuclear medicine methods in diagnostic and therapeutic procedures in human medicine.

ThyroPIX will bring an efficient instrument to meet the 2018/02 implemented EU ordinance 2013/59/EURATOM requirements on radiation therapy planning and verification which is problematical in nuclear medicine methods.

The major concern in design and development will be payed to elimination of known limitations and disadvantages which prevents the therapeutic centers to meet the requirements of the legislations which will consequently enable to apply principals of personalized medicine in administrations of the therapeutic radio-pharmaceuticals.

The main advantages of innovative camera ThyroPIX are:

  • High activity radionuclide accumulated in target volume imaging for treatment verification
  • Detection of high photon fluxes
  • High spatial resolution imaging unavailable with current state-of-art gamma cameras using collimators
  • Lowering of diagnostic activities due to high detection efficiency
  • Shortening acquisition times due to high detection efficiency
  • Combination of planar and tomographic imaging (2D and SPECT) thanks to robotic arm implementation
  • Mobile camera concept

Strategy of the consortium Radalytica, Advacam, CMI, UH Motol a CAPI is development of advanced imaging system dedicated primarily to thyroid gland monitoring

Before the administration of therapeutic radioiodine

  • providing detailed information about the size a topography of the gland’s remnants
  • providing data for the optimal radioiodine activity for those thyroid tissue remnants ablation

during the treatment

  • Verifying the distribution of therapeutic activity in the target volume
  • Providing the information about dynamics of accumulation of radioiodine

and after radioiodine treatment

  • for the determination of patient’s homecare-release radioiodine activity
Ilustrativní koncept kamery ThyroPIX

Illustrative concept of ThyroPIX camera

1. mobile base with IT and peripheries for robot motion control and acquisition parameters setting

2. robotic arm Universal Robots UR5 with safety sensors and optical system

3. hybrid pixel detector for photons detection

By final product our consortium understands the advanced camera integrating two highly innovative elements:

  • Detector in Compton camera configuration based on hybrid pixel detectors technology of physical pixel size of 55 µm
  • Collaborative robotic arm which enables as planar as 3D volume reconstruction of data acquired directly on the patient’s bed without the need of transportation to a dedicated gamma camera inspection room which minimizes the possible contamination and irradiation of the personnel and other staff

ThyroPIX will be equipped also with:

  • Proprietary hardware (control unit) and software for motion control of the robot
  • Acquisition software for data collection in planar and SPECT modes
  • Processing software
  • Software modules for compatibility and communication with systems - NIS/RIS a PACS
  • Suitable hardware (PC) with all the software packages
  • Equipment for wireless data handling
  • Optional upgrade with other software packages

Developed camera will be intended as

  • Dedicated for diagnostic imaging and imaging of therapeutic activities assuring the measurements in required number and periods
  • Offering significantly better resolutio - 2D - <2 mm a SPECT - <0,5 ml
  • Substantially shortening acquisition time because of no collimator implementation (especially in SPECT)
  • Enabling detection of high photon fluxes for verification of spatial distribution of therapeutic radiopharmaceuticals

Thanks to flexibility and automatic robotic arm positioning the patient can sit on the chair or lie down in bed win his hospital room without the need of his transportation preventing radioactive contamination. Furthermore, the constant positioning assures the correct evaluation of repeated measurements and the trend curves delineation.

The preparation for IIa risk classification healthcare device certification is also part of the project.

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